Restylane® Skinbooster Injections for the improvement of skin on the tops of toes
Restylane® Skinboosters™ are outstandingly suitable for deep hydration of the skin on the tops of toes, and their effect is long-term and safe.
In our society, youthfulness and beauty free of imperfections are sadly positively attributed and also determine interactions and positioning in the social as well as the professional environment (1). This statement also applies to the appearance of your feet.
Injectable hyaluronic acid (HA) products can be classified into two groups with different therapeutic goals for podiatry. They can either be used for augmentation and volume substitution or as with the skin boosters which are injected superficially for the revitalization of the skin (2).
The biological significance of HA for the skin as well as its excellent physicochemical properties, especially its high water-binding capacity, determine injectable HA based skinboosters for improvement of skin quality. Although native HA is ubiquitous in the human body, the largest amount is located in the skin. With 7-8 g of HA, the skin contains approximately 50-56% of the total body content. HA is a significant stabilizing component of the Extracellular Matrix (ECM), can bind large amounts of water and is essential for hydration homeostasis.
Apart from its significance as a structure substance, HA is also an important functional tissue component, because extracellular substance transport (diffusion of electrolytes, nutrients and decomposition products in the tissue) as well as the activity of the immune system are associated with the hydration status of the ECM. In addition to this, HA is pivotal for cellular processes such as proliferation, differentiation and migration. Amongst other processes, it stimulates fibroblast proliferation and activity with an increased biosynthesis of collagen and other components of the ECM. Apart from regenerative tasks such as improved wound healing under HA, it also has cell protecting properties against external noxious substances. In current studies, it is being discussed whether HA itself fulfills the function of a radical catcher for the deactivation of Reactive Oxygen Species (ROS) or whether a reaction with free radicals attacks and leads to it’s destruction [3, 4].
Restylane® Skinboosters™ are injected subcutaneously and have a clinically proven effect duration of up to 12 months [5]. The long lasting and significant effect is due to the use of non-animal stabilized hyaluronic acid (NASHA), especially in direct comparison with non-stabilized hyaluronic acid. This was proven by a number of studies including Carruthers et al. (2014) as well as Williams et al. (2009) [2, 6]. The substitution leads to a stimulation of fibroblast proliferation and activity with new synthesis of collagen, elastin and other extracellular components such as HA, leading to more skin elasticity, skin tension and moisture [7]. The positive study results are supported by high patient satisfaction. According to blinded live-rating, skin quality improved in more than 80% of the patients. 85% assessed the therapeutic success positively and stated that they would repeat the treatment. Furthermore, patients as well as blinded evaluators indicated significant aesthetic improvements on the basis of the Global Aesthetic Improvement Scale (GAIS).
1.Borelli C, Berneburg M (2010) Beauty lies in the eye of the beholder. Aspects of beauty and attractiveness. J Dtsch Dermatol Ges 8: 326–330.
2.Carruthers JD, Carruthers JA, Humphrey S (2014) Fillers and neocollagenesis. Dermatol Surg 40(12): 134–136.
3. Entwistle J, Hall CL, Turley EA (1996) HA receptors: regulators of signalling to the cytoskeleton. J Cell Biochem61: 569–577
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4.Wohlrab W, Neubert RRH, Wohlrab J (2004) Trends in Clinical and Experimental Dermatology, Vol. 3 Hyaluronsäure und Haut, Shaker Verlag, Aachen.
5.Gubanova EI et al.(2015) Injections of stabilized hyaluronic acid with a sharp needle compared with a blunt microcannula for facial skin rejuvenation: 12-month results. Poster Präsentation auf dem International Mastercourse on Aging Skin (IMCAS), Paris, Frankreich.
6.Williams S, Tamburic S, Stensvik H, Weber M (2009) Changes in skin physiology and clinical appearance after microdroplet placement of hyaluronic acid in aging hands. J Cosmet Dermatol 8: 216–225.
7.Wang F, Garza LA, Kang S, Varani J, Orringer JS, Fisher GJ, VoorheesJJ (2007) In vivo stimulation of de novo collagen production caused by cross-linked hyaluronic acid dermal filler injections in photodamaged human skin. Arch Dermatol 143: 155–163.
